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Docking studies were performed on the selected compounds
2024-05-03
Docking studies were performed on the selected compounds to explore their binding patterns and to examine SAR in more detail. The co-crystal structure of ATX in complex with PF-8380 (PDB code: ) was selected for the docking studies due to structural similarity of the most potent compound with PF-83
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po1 br The role of apelin in hepatic diseases
2024-05-03
The role of apelin in hepatic diseases The involvement of the apelin/APJ system in liver physiology and pathology has been proven in numerous studies (Table 6). For instance, in the experiment of Emam et al. [63] on rats suffering from hepatic injury, apelin decreased the levels of ALT, AST and L
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Immunohistochemistry in tissue samples showed the expression
2024-05-03
Immunohistochemistry in tissue samples showed the expression of several nuclear receptor co-activators, including NCOA1, NCOA2, NCOA3, CREBBP, and EP300, in 85–100% of cpi-613 mg tumors even some of which lacked AR expression (Boorjian et al., 2009). Knockdown of each co-activator also resulted in
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The evidence points toward a
2024-05-02
The evidence points toward a role for 12/15-LO activity in WAT in modulating chronic local inflammation and subsequent systemic metabolic decline in the obese state. However, little is known as to the role of 12- and 15-LOs in BAT. Indeed, in addition to WAT, platelet- and leukocyte-type 12-LO are e
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br Conclusions The following are the supplementary data rela
2024-04-30
Conclusions The following are the supplementary data related to this article. Author contributions Conflict of interest Funding sources This work was supported by the Canadian Institutes of Health Research [grant: MOP-79470]. Introduction Sperm cells undergo a number of physical and
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We have previously reported alterations of
2024-04-30
We have previously reported alterations of the thymus in AChR-MG patients, especially in their germinal center Solamargine (defined as CD19+CD38+ cells by flow cytometric analysis). First, we found that, in MG thymi, this subset failed to show the normal down-regulation of Bcl-2, suggesting that aut
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Language emerged among the Ach through the influence
2024-04-30
“Language” emerged among the Aché through the influence of colonizers, missionaries, Bible translators, activists, anthropologists, the media, and the State. As an object, it now circulates in books, cellphones, political debates, at cultural events, on the radio, and even the Internet. It emerged a
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Introduction Microdialysis is an in
2024-04-30
Introduction Microdialysis is an in vivo-technique which allows continuous sampling of small molecular weight substances (such as neurotransmitters, metabolites and neuropeptides) from the extracellular space of different tissues or organs, e.g. brain, muscle or skin. While the implantation of the
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br Animals Female Sprague Dawley SD rats aged months with
2024-04-30
Animals Female Sprague Dawley (SD) rats, aged 3 months with body weight between 180-210 g were housed in cages and acclimatized to standardized lab conditions (temperature 23 ± 2°C, humidity 50 ± 5% and 12 h light-dark cycles). The rats were fed with standard rodent food pellet (Harlan Diet, Ross
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The analysis of the profile of protein phosphorylation in
2024-04-30
The analysis of the profile of protein phosphorylation in MMS-treated calpain inhibitor confirmed that both the ATM and ATR pathways were activated in S-phase blocked cells. Interestingly, phosphorylation of Chk1 was observed 24h after MMS-treatment both in AT- and ATM-inhibited cells, whilst in th
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br Application of bamboo in the food and pharmaceutical indu
2024-04-30
Application of bamboo in the food and pharmaceutical industry For decades, the application of antioxidants in the food and pharmaceutical industry has been widespread. In the past, antioxidants were previously used to control oxidation and retard spoilage but today, many are used because of putat
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HMGN proteins are subject to
2024-04-30
HMGN proteins are subject to extensive post-translational modifications which influence both their mode of binding to Necrostatin 1 synthesis and their functional activity. Like the other HMG protein families, HMGNs are substrates for many of the same enzymes that modify histone proteins (review in
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Since HETEs and lipoxins the downstream products of LOX from
2024-04-29
Since HETEs and lipoxins, the downstream products of 12/15-LOX from AA, may alter cellular proliferation and apoptosis,31, 32 and possibly explain the increase of tumour progression and metastasis. However, we here found that HETEs did not affect the proliferation of melanoma in vitro. This may par
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br Funding br Introduction Plants absorb both inorganic nitr
2024-04-29
Funding Introduction Plants absorb both inorganic nitrogen (ammonium and nitrate) and organic nitrogen (amino acids and peptides) from the soil [1]. The first organic nitrogenous molecule produced from inorganic nitrogen is Gln, whose terminal amino group is successively transferred to make Gl
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In AD and possibly other forms of dementia
2024-04-29
In AD, and possibly other forms of dementia, it has been suggested that tau mislocalization to dendritic spines anticipates neurodegeneration [48]. Accumulation of hyperphosphorylated tau in dendritic spies would cause a derangement of synaptic function, thereby impairing excitatory synaptic transmi
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