• It was recently reported that a functional single nucleotide

  2020-02-18

  

  It was recently reported that a functional single nucleotide polymorphism (rs75932628) within Triggering receptor expressed on myeloid DMAT mg 2 (TREM2) is associated with AD (Guerreiro et al., 2013). Homozygous loss of function mutations in TREM2 are also associated with an autosomal recessive for

• br Disclosures br Introduction The

  2020-02-18

  

  Disclosures Introduction The presence of anti-viral T-cell immunity is crucial for effective and sustained protection against Cytomegalovirus (CMV) following allogeneic stem cell transplantation (alloSCT) [1]. In vitro and in vivo T-cell depletion (TCD) via addition of the anti-CD52 monoclonal

• Introduction The physiological significance of hypoxia

  2020-02-18

  

  Introduction The physiological significance of hypoxia is undisputed, although largely over looked in the cancer therapeutics field focused on DNA-damage induced by ionizing radiation or drug treatment. Regions of hypoxia occur during a range of diverse biological situations including embryogenesis

• br Clinical potential of ET receptor biased ligands Is

  2020-02-18

  

  Clinical potential of ET receptor biased ligands Is there a clinical need for ET receptor biased ligands? Evidence is strongest from research in epithelial ovarian cancer demonstrating that ET-1 stimulated ETA-mediated β-arrestin signalling leads to activation of the oncogenic mediator NF-κB [21]

• Besides EGFR other tyrosine kinase receptors are currently g

  2020-02-18

  

  Besides EGFR, other tyrosine kinase receptors are currently gaining attention as potential therapeutic targets. Included among these is the fibroblast growth factor receptor (FGFR) family, which is involved in the progression of a variety of cancers.7, 8, 9, 10, 11 In lung cancer, fibroblast growth

• br Introduction Melatonin mainly originates from

  2020-02-18

  

  Introduction Melatonin mainly originates from the pineal gland (Reiter, 1991) and is well known for its physiological functions in the regulation of circadian rhythms (Cajochen et al., 2003) and as a potent free radical scavenger and broad-spectrum antioxidant in mammals (Paradies et al., 2010, T

• MicroRNA miRNA is a class of highly conserved non coding

  2020-02-18

  

  MicroRNA (miRNA) is a class of highly conserved, non-coding small molecules containing 19–25 nucleotides. miRNAs are involved in the regulation of genes associated with cancer development and progression and therefore can act as oncogenes, by contributing to tumor formation,17, 18 or as tumor suppre

• br Concluding remarks A crucial

  2020-02-18

  

  Concluding remarks A crucial step in the microbial degradation of steroids is the 1(2)-dehydrogenation of the steroid nucleus by FAD-dependent Δ1-KSTDs. This step is required to initiate the opening of the steroid nucleus under both aerobic and anaerobic conditions. A large variety of steroid-deg

• OHC is a potent regulator of LXR

  2020-02-17

  

  25-OHC is a potent regulator of LXR-mediated pathways, that impact on Diclofenac lipid homeostasis [8]. This oxysterol affects expression of the cholesterol efflux pumps ATP-binding cassette transporter (ABC)A1 [9] and ABCG1, and expression of apolipoprotein E [10], [11], [12]. 25-OHC is able to st

• The DDR mediated lysyl oxidase induction in

  2020-02-17

  

  The DDR2-mediated lysyl oxidase induction in osteoblasts reported here is a novel function for this receptor. Various functions have been reported for DDR2. In an in-vitro study, Zhang and colleagues showed that DDR2 activation leads to Runx2 phosphorylation, which regulates osteoblast differentiati

• Today many strategies have been developed to enhance

  2020-02-17

  

  Today, many strategies have been developed to enhance CXCR-4 receptor 25-hydroxyvitamin d3 synthesis on the cell surface, either by modifying the cell culture medium or by modifying the CXCR-4 gene in BMSCs to stimulate stem cell recruitment (Jiang et al., 2012, Liu et al., 2014b). For instance, th

• Social memory is encoded within

  2020-02-17

  

  Social memory is encoded within certain sites, but meaning depends upon an interpretant (such as a tourist) being able to decode the signs. Memorials, such as cemeteries, require some kind of activity by its visitors for their meanings to be activated (Hutchinson, 2009, Winter, 2010). Following Eden

• lxr agonist br Discussion EFTs are sarcomas with

  2020-02-17

  

  Discussion EFTs are sarcomas with almost undifferentiated histologic features, consequently their differentiation from other small, blue, round cell tumors may be difficult. Substantial intracellular lxr agonist on PAS stain is a useful diagnostic feature. The addition of CD99 and FLI1 immunohis

• cAMP mediated signaling pathways are important for

  2020-02-17

  

  cAMP-mediated signaling pathways are important for maintaining metabolic homeostasis, and the effects of the glucagon/catecholamine–cAMP–PKA axis on energy balance have been well documented [20]. For example, Cathepsin S inhibitor of the PKA 2β regulatory subunit (RIIβ) in mice leads to increased e

• In this report we describe studies of the effects of

  2020-02-17

  

  In this report we describe studies of the effects of peroxisome proliferator-activated receptor γ (PPARγ) and acyl-CoA synthetase (ACSL1) on palmitate-induced ER stress in the human cardiomyocyte-like cell line AC16 [22], which was derived from adult ventricular heart tissue. PPARγ is a nuclear rece

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